We offer Western blot/IP detection based on modification-specific antibodies, as well as mass-spectrometry-based post-translational modification (PTM) identification, covering common modification types such as phosphorylation, acetylation, ubiquitination, and methylation.
When you suspect that a change in a protein’s function isn’t due to a change in its expression level but rather a change in its modification state — such as phosphorylation or acetylation — PTM detection helps you confirm that "hidden" layer of regulation — answering "the amount of protein hasn’t changed, but has its ‘state’ changed."
Modification-specific antibodies recognize a particular modification site or type and are combined with immunoprecipitation enrichment followed by WB detection; mass spectrometry methods enrich modified peptides and use tandem mass spectrometry to identify modification sites and extent, enabling whole-proteome-scale modification-profile analysis.
Research into signaling pathway activation state, mechanisms regulating protein stability, drug mechanism of action research, etc.
Phosphorylation, acetylation, ubiquitination, methylation
Antibody-based or mass-spectrometry-based methods available
Complete detection data delivered
Mass spectrometry enables in-depth modification-profile analysis
Submit your experimental plan and objectives
Technical advisor confirms the protocol and timeline
Pay a deposit of at least 50% of the project cost to enter production
Quality control documented throughout production
Settle the balance and complete acceptance
Standard, custom, and large orders all require a deposit of at least 50% of the contract value to begin. The timing for the remaining balance is agreed separately for each project.
Please complete acceptance within 1 month of receiving the product or report. Any concerns about the deliverable should be raised within this window; we will respond within 2 business days.