Based on in vitro transcription (IVT) technology, we synthesize mRNA, sgRNA, siRNA, lncRNA, and other functional RNAs, supporting 5' capping, 3' poly(A) tailing, and modified base incorporation such as pseudouridine, to improve stability and translation efficiency.
When you need off-the-shelf siRNA, miRNA mimics/inhibitors, or other functional RNA without going through the longer route of plasmid construction followed by in vitro transcription, direct chemical/enzymatic RNA synthesis can substantially shorten your turnaround — answering "what’s the fastest way to get the RNA I need."
Built around T7/T3/SP6 RNA polymerase, template DNA is transcribed in vitro to generate the RNA strand; modified bases are incorporated by substituting natural nucleotide triphosphates (NTPs) during transcription. Capping can be achieved co-transcriptionally (ARCA-type analogs) or post-transcriptionally by enzymatic methods (capping enzyme + 2'-O-methyltransferase). The product is then treated with DNase to remove the template, purified, and QC-tested to confirm integrity and purity.
mRNA vaccine/therapeutic mRNA research, in vitro delivery of CRISPR sgRNA, siRNA gene silencing, RNA structure and function research, etc.
Cap0/Cap1 capping, poly(A) tailing, pseudouridine (Ψ)/N1-methylpseudouridine incorporation
Delivered with a concentration and integrity QC report
Denaturing or capillary electrophoresis confirms integrity and purity
mRNA vaccine research, sgRNA delivery, siRNA silencing, and more
Submit your experimental plan and objectives
Technical advisor confirms the protocol and timeline
Pay a deposit of at least 50% of the project cost to enter production
Quality control documented throughout production
Settle the balance and complete acceptance
Standard, custom, and large orders all require a deposit of at least 50% of the contract value to begin. The timing for the remaining balance is agreed separately for each project.
Please complete acceptance within 1 month of receiving the product or report. Any concerns about the deliverable should be raised within this window; we will respond within 2 business days.